Article
An overview of the genes and biomarkers in Alzheimer's disease.
Ageing research reviews - 1 Feb 2025
Krishnamurthy Hari Krishnan, Jayaraman Vasanth, Krishna Karthik, Wang Tianhao, Bei Kang, Changalath Chithra, Rajasekaran John J
Abstract excerpt
Alzheimer's disease (AD) is the most common type of dementia and neurodegenerative disease characterized by neurofibrillary tangles (NFTs) and amyloid plaque. Familial AD is caused by mutations in the APP, PSEN1, and PSEN2 genes and these mutations result in the early onset of the disease. Sporadic AD usually affects older adults over the age of 65 years and is, therefore classified as late-onset AD (LOAD)....
Topics
- Humans
- Alzheimer Disease
- Biomarkers
- Genetic Predisposition to Disease