Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isoform-specific targeting of PKA to multivesicular bodies.

The Journal of cell biology - 18 Apr 2011

Day Michele E, Gaietta Guido M, Sastri Mira, Koller Antonius, Mackey Mason R, Scott John D, Perkins Guy A, Ellisman Mark H, Taylor Susan S

Abstract excerpt

Although RII protein kinase A (PKA) regulatory subunits are constitutively localized to discrete cellular compartments through binding to A-kinase-anchoring proteins (AKAPs), RI subunits are primarily diffuse in the cytoplasm. In this paper, we report a novel AKAP-dependent localization of RIα to distinct organelles, specifically, multivesicular bodies (MVBs). This localization depends on binding to AKAP11, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A Kinase Anchor Proteins
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

Share to Gene Knockdown Techniques

Share to HEK293 Cells

Share to HeLa Cells

Share to Isoenzymes

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 21502359
DOI: 10.1083/jcb.201010034
PMCID: PMC3080257

Genes

AKAP11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isoform-specific targeting of PKA to multivesicular bodies.PMID 21502359Read ↗

Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity.Semantic proximity Read ↗

Deletion of type IIalpha regulatory subunit delocalizes protein kinase A in mouse sperm without affecting motility or fertilization.Semantic proximity Read ↗

Local protein kinase A signaling pathologies in the endocrine system.Semantic proximity Read ↗

Selective knockout of PKA regulatory subunits reveal opposite catalytic and metabolic consequences with implications for Alzheimer’s diseaseSemantic proximity Read ↗

A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species.Semantic proximity Read ↗

Phase separation of a PKA type I regulatory subunit regulates β-cell function through cAMP compartmentalization.Semantic proximity Read ↗

Recurrent Acrodysostosis-Related PKA RIα Mutant Reveals a Novel Mechanism of Aberrant PKA Deactivation.Semantic proximity Read ↗

Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA, a neurodegenerative disease in which the RIβ-L50R variant is expressedSemantic proximity Read ↗

Characterization of structural features that mediate the tethering of Caenorhabditis elegans protein kinase A to a novel A kinase anchor protein. Insights into the anchoring of PKAI isoforms.Semantic proximity Read ↗

Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complexSemantic proximity Read ↗

The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study.Semantic proximity Read ↗

The ways in which hormones change cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunits, and how such changes affect cell behavior.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.