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New Delhi Metallo-β-Lactamase: Structural Insights into β-Lactam Recognition and Inhibition

19 Jun 2012

Abstract excerpt

The β-lactam antibiotics have long been a cornerstone for the treatment of bacterial disease. Recently, a readily transferable antibiotic resistance factor called the New Delhi metallo-β-lactamase-1 (NDM-1) has been found to confer enteric bacteria resistance to nearly all β-lactams, including the heralded carbapenems, posing a serious threat to human health. The crystal structure of NDM-1 bound to meropenem...

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PMID: 22713171
DOI: 10.1021/ja303579d

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