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Rapid detection and capture of clinical Escherichia coli strains mediated by OmpA-targeting nanobodies

14 Jul 2025

Abstract excerpt

Escherichia coli is a major cause of blood stream and urinary tract infections. Owing to the spread of antimicrobial resistance, it is often treated with an inadequate antibiotic. With the aim to accelerate the diagnostics of this key pathogen, we used the flycode technology to generate nanobodies against the conserved and highly abundant outer membrane protein OmpA. Two nanobodies each recognizing a different...

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PMID: 40659774
DOI: 10.1038/s42003-025-08345-9

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