Article

Nanopore sequencing elucidates in-vivo development of meropenem resistance by insertion of a mobile genetic element in the porin gene ompC in E. coli.

2024-01-19

Abstract excerpt

An ESBL-producing E. coli-isolate recovered from a patient undergoing long-term treatment developed resistance to meropenem without acquiring carbapenem-hydrolysing enzymes. We performed Nanopore and Illumina sequencing and subsequent full hybrid genome assembly of this isolate and the meropenem-susceptible isolate recovered almost 8 weeks prior. Whole genome MLST patterns did not differ between isolates. However,...

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Literature Corpus work: 33735664-2d86-5631-8813-b86f66a3c15f
DOI: 10.1099/acmi.0.000757.v2

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