Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine design

2 Feb 2021

Abstract excerpt

Enterotoxigenic Escherichia coli (ETEC) is estimated to cause approximately 380,000 deaths annually during sporadic or epidemic outbreaks worldwide. Development of vaccines against ETEC is very challenging due to the vast heterogeneity of the ETEC strains. An effective vaccines would have to be multicomponent to provide coverage of over ten ETEC strains with genetic variabilities. There is currently no vaccine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriophages and microbial interactions
Share to Escherichia coli research studies
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33531570
DOI: 10.1038/s41598-021-81895-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anti-CfaE nanobodies provide broad cross-protection against major pathogenic enterotoxigenic Escherichia coli strains, with implications for vaccine designPMID 33531570Read ↗

Targeting Enterotoxins: Advancing Vaccine Development for Enterotoxigenic Escherichia coli ETECSemantic proximity Read ↗

Identification and Characterization of Human Monoclonal Antibodies for Immunoprophylaxis Against Enterotoxigenic Escherichia coli InfectionSemantic proximity Read ↗

Repeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic <i>E. coli adhesin</i>Semantic proximity Read ↗

Interrogation of a live-attenuated enterotoxigenic Escherichia coli vaccine highlights features unique to wild-type infectionSemantic proximity Read ↗

Vaccines against extraintestinal pathogenic Escherichia coli (ExPEC): progress and challengesSemantic proximity Read ↗

Selection of Nanobodies that Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDTSemantic proximity Read ↗

Identification of cross-reactive vaccine antigen candidates in Gram-positive ESKAPE pathogens through subtractive proteome analysis using opsonic seraSemantic proximity Read ↗

Protective Enterotoxigenic Escherichia coli Antigens in a Murine Intranasal Challenge ModelSemantic proximity Read ↗

Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivoSemantic proximity Read ↗

Contribution of noncanonical antigens to virulence and adaptive immunity in human infection with enterotoxigenic <i>E. coli</i>Semantic proximity Read ↗

Conservation and global distribution of non-canonical antigens in Enterotoxigenic Escherichia coli.Semantic proximity Read ↗

Vaccines Against Shigella and Enterotoxigenic Escherichia coli: A summary of the 2018 VASE ConferenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.