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A different function for a member of an ancient and highly conserved cytochrome P450 family: From essential sterols to plant defense

21 Nov 2006

Abstract excerpt

CYP51 sterol demethylases are the only cytochrome P450 enzymes with a conserved function across the animal, fungal, and plant kingdoms (in the synthesis of essential sterols). These highly conserved enzymes, which are important targets for cholesterol-lowering drugs, antifungal agents, and herbicides, are regarded as the most ancient member cytochrome P450 family. Here we present a report of a CYP51 enzyme that...

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PMID: 17124172
DOI: 10.1073/pnas.0607849103

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