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Stem and progenitor cell proliferation are independently regulated by cell type-specific cyclinD genes

14 Jul 2025

Abstract excerpt

Regeneration and homeostatic turnover of solid tissues depend on the proliferation of symmetrically dividing adult stem cells, which either remain stem cells or differentiate based on their niche position. Here we demonstrate that in zebrafish lateral line sensory organs, stem and progenitor cell proliferation are independently regulated by two cyclinD genes. Loss of ccnd2a impairs stem cell proliferation during...

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PMID: 40659618
DOI: 10.1038/s41467-025-60251-0

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