Enhanced catalytic performance and pH stability of Streptomyces Laccase Y230R and its degradation of malachite green.

doi:10.1016/j.ijbiomac.2024.134108

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Article

Enhanced catalytic performance and pH stability of Streptomyces Laccase Y230R and its degradation of malachite green.

International journal of biological macromolecules - 1 Oct 2024

Bian Luyao, Zhang Silu, Chang Tingting, Zhang Jiacheng, Zhu Xiaoyu, Zhang Chong

Abstract excerpt

The escalating threat of malachite green (MG) pollution poses significant risks to ecosystems. Saturation mutation targeting Tyr230 of small laccase (SLAC) from Streptomyces coelicolor yielded Y230R, exhibiting a remarkable 104 % increase in specific activity. Notably, this mutation achieved dual enhancements in both activity and pH stability. Molecular dynamics simulation revealed higher structural stability of...

Topics

Biocatalysis
Catalysis
Enzyme Stability
Hydrogen Bonding
Hydrogen-Ion Concentration
Kinetics
Laccase
Molecular Docking Simulation
Molecular Dynamics Simulation
Mutation
Rosaniline Dyes
Streptomyces

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Identifiers

PMID: 39048010
DOI: 10.1016/j.ijbiomac.2024.134108

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