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Cellular Senescence in Health, Disease, and Lens Aging

12 Feb 2025

Abstract excerpt

Background: Cellular senescence is a state of irreversible cell cycle arrest that serves as a critical regulator of tissue homeostasis, aging, and disease. While transient senescence contributes to development, wound healing, and tumor suppression, chronic senescence drives inflammation, tissue dysfunction, and age-related pathologies, including cataracts. Lens epithelial cells (LECs), essential for maintaining...

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PMID: 40006057
DOI: 10.3390/ph18020244

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