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Association of CpG site of MTHFR gene promoter and type 2 diabetes in Moroccan population susceptibility.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2026

El Alami Houda, Bouqdayr Meryem, Errafii Khaoula, Messaoudi Nouha, Sehli Sofia, Al Idrissi Najib, Abidi Omar, Rhalem Wajih, Khlil Naima, Ghazal Hassan, Hamdi Salsabil

Abstract excerpt

Type 2 diabetes (T2D) is a complex multifactorial metabolic disorder characterized by progressive disease progression, involving varying degrees of insulin resistance and pancreatic islet dysfunction. Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme regulating folate metabolism, and its polymorphisms have been associated with T2D. However, the methylation pattern of the MTHFR gene has not been...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 40638835
DOI: 10.1080/15257770.2025.2532089

Genes

MTHFR

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