Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility.

doi:10.1002/mgg3.1020

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Article

Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility.

Molecular genetics & genomic medicine - 1 Dec 2019

Meng Yanzi, Liu Xiaoling, Ma Kai, Zhang Lili, Lu Mao, Zhao Minsu, Guan Min-Xin, Qin Guijun

Abstract excerpt

INTRODUCTION: Methylenetetrahydrofolate reductase (MTHFR) is essential in mediating folate metabolism, and thus plays an important role in diabetes and diabetic complications. MTHFR C677T (rs1801133 C>T) polymorphism has been proposed to be linked with type 2 diabetes mellitus (T2DM) susceptibility. However, the conclusions are inconsistent. Therefore, we rechecked their linkage aiming to obtain a more reliable...

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PMID: 31663297
DOI: 10.1002/mgg3.1020
PMCID: PMC6900375

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