Association analysis of MTHFR (rs1801133 and rs1801131) gene polymorphism towards the development of type 2 diabetes mellitus in Dali area population from Yunnan Province, China.

doi:10.7717/peerj.18334

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Association analysis of MTHFR (rs1801133 and rs1801131) gene polymorphism towards the development of type 2 diabetes mellitus in Dali area population from Yunnan Province, China.

PeerJ - 1 Jan 2024

Liu Yongxin, Pu Genyuan, Yang Caiting, Wang Yuqing, Jin Kaitai, Wang Shengrong, Liang Xiao, Hu Shenghe, Sun Shuguang, Lai Mingming

Abstract excerpt

Background: Type 2 diabetes mellitus (T2DM) is a common complex metabolic disorder that exhibits a strong genetic predisposition. 5,10-methylenetetrahydrofolate reductase (MTHFR) regulates folate metabolism, which has been proposed to be associated with T2DM, although the relationship is inconsistent among different geographical areas. This study aimed to investigate the effects of MTHFR C677T (rs1801133) and...

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Identifiers

PMID: 39465169
DOI: 10.7717/peerj.18334
PMCID: PMC11512809

Genes

MTHFR
TNF

Variants

rs1801133
rs1801133

Provenance

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