Article
Methylenetetrahydrofolate reductase C677T polymorphism and type 2 diabetes mellitus in Chinese population: a meta-analysis of 29 case-control studies.
PloS one - 1 Jan 2014
Zhu Bo, Wu Xiaomei, Zhi Xueyuan, Liu Lei, Zheng Quanmei, Sun Guifan
Abstract excerpt
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, had significant effects on the homocysteine levels. The common functional MTHFR C677T polymorphism had been extensively researched. Several studies had evaluated the relationship between MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM), but the results were still controversial in the Chinese Han population....
Topics
- Alleles
- Asian People
- Case-Control Studies
- Diabetes Mellitus, Type 2
- Genetic Predisposition to Disease
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Polymorphism, Single Nucleotide