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Hypermethylation in the promoter of the MTHFR gene is associated with diabetic complications and biochemical indicators

18 Oct 2017

Abstract excerpt

DNA methylation is an epigenetic mechanism for regulating the transcription of many genes and has been linked to the development of various diseases. A promising gene to investigate is methylenetetrahydrofolate reductase (MTHFR), since the enzyme methylenetetrahydrofolate reductase (MTHFR) promotes methyl radical synthesis in the homocysteine cycle and can provide methyl groups for DNA methylation. In addition,...

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PMID: 29075332
DOI: 10.1186/s13098-017-0284-3

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