Article
Molecular epidemiology of the MTHFR C677T polymorphism and its association with type 2 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital.
Annals of human biology - 1 Dec 2026
Kassahun Berie Genetu, Dagnaw Mequanente, Indracanti Meera, Dejen Muluken, Berhane Nega
Abstract excerpt
BACKGROUND: Type 2 diabetes mellitus (T2DM) is marked by chronic hyperglycemia from impaired insulin secretion and action. The MTHFR C677T variant, affecting folate metabolism and homocysteine, has been linked to T2DM, though evidence is inconsistent, especially in Ethiopia. AIM: The objective of this study was to investigate the association of MTHFR C677T gene polymorphism and the risk of T2DM among patients...
Topics
- Humans
- Diabetes Mellitus, Type 2
- Methylenetetrahydrofolate Reductase (NADPH2)
- Middle Aged
- Female
- Male
- Ethiopia
- Adult
- Cross-Sectional Studies
- Polymorphism, Single Nucleotide
- Young Adult
- Aged
- Molecular Epidemiology
- Genetic Predisposition to Disease