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Article

Effect of CYP3A4 Methylation on Tacrolimus Pharmacokinetics.

Therapeutic drug monitoring - 1 Dec 2025

Koudijs Karel K M, Etsouli Oumaima, Vallerga Costanza L, Moes Dirk Jan A R, Ruijter Bastian N, Swen Jesse J, Coenraad Minneke J, van Gelder Teun

Abstract excerpt

BACKGROUND: Common genetic variants in CYP3A4 together only explain a limited amount of the variability in tacrolimus clearance. This cross-sectional study aimed to explore the extent to which pharmacokinetic variability can be explained by methylation of the CYP3A4 gene. METHODS: Residual tissue material from liver biopsies routinely collected 6 months post-transplantation was used. Inclusion criteria were...

Read the complete abstract on PubMed

Topics

Humans
Cytochrome P-450 CYP3A
Tacrolimus
Male
Female
Cross-Sectional Studies
Immunosuppressive Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Adult

Liver

Genotype

DNA Methylation

Methylation

Liver Transplantation

Area Under Curve

Source

Open in PubMed Open full text

Identifiers

PMID: 40632895
DOI: 10.1097/FTD.0000000000001351
PMCID: PMC12588635

Genes

CYP3A4
CYP3A5

Provenance

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