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Article

The Genetic Polymorphism of CYP3A4 rs2242480 is Associated with Sirolimus Trough Concentrations Among Adult Renal Transplant Recipients.

Current drug metabolism - 1 Jan 2020

Lolita Lolita, Zheng Ming, Zhang Xiang, Han Zhijian, Tao Jun, Fei Shuang, Wang Zijie, Guo Miao, Yang Haiwei, Ju Xiaobing, Tan Ruoyun, Wei Ji-Fu, Gu Min

Abstract excerpt

BACKGROUND: The large interindividual variability in the genetic polymorphisms of sirolimus (SIR)- metabolizing enzymes, transporters, and receptors can lead to qualitatively and quantitatively distinct therapeutic responses. OBJECTIVE: We examined the impact of numerous candidate single-nucleotide polymorphisms (SNPs) involved in the trough concentration of SIR-based immunosuppressant regimen. METHODS: This is a...

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Share to Cytochrome P-450 CYP3A
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 33115392
DOI: 10.2174/1389200221999201027203401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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