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The Extracellular Matrix Regulates Cancer Progression and Therapy Response: Implications for Prognosis and Treatment

31 Mar 2009

Abstract excerpt

Emerging evidence points towards a key role of the extracellular matrix (ECM) during tumor progression and therapy resistance. Paradoxically, in today's routine of cancer management the ECM is not taken into account. It is the aim of the present review to broaden our understanding of the mechanisms of therapy resistance, taking the ECM as a presumptive central regulator. The stromal ecosystem drives the...

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PMID: 19355975
DOI: 10.2174/138161209787846711

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