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Article

Compensatory Evolution Following Deleterious Episodes of GC-biased Gene Conversion in Rodents.

Molecular biology and evolution - 1 Jul 2025

Riffis Marie, Saclier Nathanaëlle, Galtier Nicolas

Abstract excerpt

GC-biased gene conversion (gBGC) is a widespread evolutionary force associated with meiotic recombination that favors the accumulation of deleterious AT to GC substitutions in proteins, moving them away from their fitness optimum. In many mammals, recombination hotspots have a rapid turnover, leading to episodic gBGC, with the accumulation of deleterious mutations stopping when the recombination hotspot dies....

Read the complete abstract on PubMed

Topics

Gene Conversion
Animals
Evolution, Molecular
Phylogeny
Base Composition
Rodentia
Selection, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Exons

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40629524
DOI: 10.1093/molbev/msaf168
PMCID: PMC12290510

Genes

GC

Provenance

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