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Article

Modulating ovarian cancer progression through FDX1-driven autophagy

8 Jul 2025

Abstract excerpt

Ferredoxin 1 (FDX1) emerges as a crucial regulator of autophagy and copper metabolism in ovarian cancer (OC), as revealed by this investigation. Predominantly localized to the cytoplasm and mitochondria, FDX1 coordinates autophagic activity by modulating the AMPK and mTOR signaling pathways. Its role extends to preserving mitochondrial integrity and facilitating sulfation of DLAT/DLST, ensuring effective...

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PMID: 40629130
DOI: 10.1038/s41698-025-00994-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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