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Article

Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy

9 Dec 2022

Abstract excerpt

Abstract Chemoresistance has long been the bottleneck of ovarian cancer (OC) prognosis. It has been shown that mitochondria play a crucial role in cell response to chemotherapy and that dysregulated mitochondrial dynamics is intricately linked with diseases like OC, but the underlying mechanisms remain equivocal. Here, we demonstrate a new mechanism where CRL4CUL4A/DDB1 manipulates OC cell chemoresistance by...

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PMID: 36481655
DOI: 10.1038/s41392-022-01253-y

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