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FDX1 inhibits thyroid cancer malignant progression by inducing cuprotosis

26 Jul 2023

Abstract excerpt

Cuprotosis is a recently identified cell death form that caused by intracellular copper accumulation and regulated by FDX1. This work aimed to explore the role of cuprotosis and the pivotal regulatory gene FDX1 in thyroid cancer development. We observed that expression of FDX1 in tumor section was notably lower than that in non-tumor sections in clinical samples. Induction of cuprotosis by elesclomol (ES)...

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PMID: 37554785
DOI: 10.1016/j.heliyon.2023.e18655

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