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LncRNA PVT1 promotes cuproptosis through transcriptional activation of FDX1 in colorectal cancer

7 Jun 2025

Abstract excerpt

BACKGROUND: Cuproptosis, a copper-dependent form of regulated cell death, has emerged as a redox-sensitive vulnerability in cancer. However, the molecular basis by which this process is initiated and sustained in tumors remains poorly defined. METHODS: We investigated the functional role of FDX1 in cuproptosis in colorectal cancer through a series of in vivo and in vitro assays. Differential gene expression...

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PMID: 40505346
DOI: 10.1016/j.redox.2025.103722

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