Article
Tofacitinib Mitigates the Increased SARS-CoV-2 Infection Susceptibility Caused by an IBD Risk Variant in the PTPN2 Gene.
Cellular and molecular gastroenterology and hepatology - 1 Jan 2025
Spalinger Marianne R, Sanati Golshid, Chatterjee Pritha, Hai Rong, Li Jiang, Santos Alina N, Nordgren Tara M, Tremblay Michel L, Eckmann Lars, Hanson Elaine, Scharl Michael, Wu Xiwei, Boland Brigid S, McCole Declan F
Abstract excerpt
BACKGROUND & AIMS: Coronavirus disease (COVID-19), caused by severe acquired respiratory syndrome-Coronavirus-2 (SARS-CoV-2), triggered a global pandemic with severe medical and socioeconomic consequences. Although fatality rates are higher among the elderly and those with underlying comorbidities, host factors that promote susceptibility to SARS-CoV-2 infection and severe disease are poorly understood. Although...
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- Humans
- Piperidines
- COVID-19
- Protein Tyrosine Phosphatase, Non-Receptor Type 2
- Animals