Article
Hypoxia- and mechanical stress-induced upregulation of mitochondrial HSP60 is associated with phenotypic switching of pulmonary arterial smooth muscle cells.
Cell stress & chaperones - 1 Jul 2025
Liu Geng, Nie Han, Zhang Xu, Huang Zi-Sheng, Yoshiura Koh-Ichiro, Liu Ke-Xiang, Liu Yi, Li Tao-Sheng
Abstract excerpt
BACKGROUND: Switching from a contractile to a synthetic phenotype of pulmonary arterial smooth muscle cells (PASMCs) is known to play a crucial role in pulmonary arterial hypertension (PAH). We investigated how hypoxia and mechanical stress mediate the phenotypic switching of PASMCs. METHODS: Human PASMCs were used for experiments. Hypoxia treatment was done by culturing cells under 1% O₂. Mechanical stress was...
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