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Mechanisms and effects of NLRP3 in digestive cancers

5 Jan 2024

Abstract excerpt

Inflammasomes are thought to be important mediators of host defense against microbial pathogens and maintenance of gastrointestinal tract homeostasis. They can modulate caspase-1 to promote IL-18 and IL-1β secretion and promote phagocytosis induced by bacterial pathogens. NLRP3 is an inflammasome comprising a multiprotein complex assembled by pattern recognition receptors in the cell cytoplasm. It is a crucial...

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PMID: 38182564
DOI: 10.1038/s41420-023-01783-6

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