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Article

Somatic mosaicism in healthy human tissues.

Trends in genetics : TIG - 1 Jun 2011

De Subhajyoti

Abstract excerpt

From the fertilization of an egg until the death of an individual, somatic cells can accumulate genetic changes, such that cells from different tissues or even within the same tissue differ genetically. The presence of multiple cell clones with distinct genotypes in the same individual is referred to as 'somatic mosaicism'. Many endogenous factors such as mobile elements, DNA polymerase slippage, DNA...

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PMID: 21496937
DOI: 10.1016/j.tig.2011.03.002

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