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Depleting retinoic acid synthesis in the nucleus accumbens shell produces a protective phenotype for emotional reactivity and drug-taking in rats.

Psychopharmacology - 1 Jan 2026

Mármol Contreras Yorkiris, Dvorak Nolan M, Tapia Cynthia M, Zaman Roxana, Annareddy Jyothika, Balikosa Yves, Gupta Nikita S, Rader Alex P, Vasquez Tileena E S, Koshy Shyny, Li Dingge, Balaji Varun K, Laezza Fernanda, Green Thomas A

Abstract excerpt

RATIONALE: In previous work, a convergent transcriptomic approach strongly suggested a role for retinoic acid (RA) in controlling the emotion- and reward-related functions of the nucleus accumbens shell (NAcSh). OBJECTIVE: Here, we causally assess the role of NAcSh RA in controlling anxiety-, emotion-, and reward-related behavior in rats and explore cellular mechanisms that may underlie this phenotype. METHODS:...

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PMID: 40601035
DOI: 10.1007/s00213-025-06838-3
PMCID: PMC13019352

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