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Loss of CFHR5 function reduces the risk for age-related macular degeneration

1 Jul 2025

Abstract excerpt

Age-related macular degeneration (AMD) is a prevalent cause of vision loss in the elderly with limited therapeutic options. A single chromosomal region around the complement factor H gene (CFH) is reported to explain nearly 25% of genetic AMD risk. Here, we used association testing, statistical finemapping and conditional analyses in 12,495 AMD cases and 461,686 controls to deconvolute four major CFH haplotypes...

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PMID: 40593839
DOI: 10.1038/s41467-025-61193-3

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Loss of CFHR5 function reduces the risk for age-related macular degenerationPMID 40593839Read ↗

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