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Article

Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2/HTRA1 loci.

Human genomics - 25 Sept 2021

Pappas Chris M, Zouache Moussa A, Matthews Stacie, Faust Caitlin D, Hageman Jill L, Williams Brandi L, Richards Burt T, Hageman Gregory S

Abstract excerpt

BACKGROUND: Single-variant associations with age-related macular degeneration (AMD), one of the most prevalent causes of irreversible vision loss worldwide, have been studied extensively. However, because of a lack of refinement of these associations, there remains considerable ambiguity regarding what constitutes genetic risk and/or protection for this disease, and how genetic combinations affect this risk. In...

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Identifiers

PMID: 34563268
DOI: 10.1186/s40246-021-00359-8
PMCID: PMC8466924

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Protective chromosome 1q32 haplotypes mitigate risk for age-related macular degeneration associated with the CFH-CFHR5 and ARMS2/HTRA1 loci.PMID 34563268Read ↗

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