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Immune-Derived THBS1-CD47 Axis Induces Cellular Senescence and Suppresses Osteogenesis in Diabetic Periosteum

2025-11-19

Abstract excerpt

Type 2 diabetes mellitus (T2DM) weakens bone repair and increases fracture risk, but how the periosteal environment contributes to this problem is not fully understood. We found that diabetic mice showed thinning of the periosteum, reduced bone mass, and poor function of bone-forming cells. Using single-cell RNA sequencing, we discovered that immune cells and bone-lineage cells interact more strongly in diabetes t...

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Identifiers and source

Literature Corpus work
d89ab025-642a-544f-9255-8a2ead1b8759
DOI
10.1101/2025.11.19.689158
Open publication

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Immune-Derived THBS1-CD47 Axis Induces Cellular Senescence and Suppresses Osteogenesis in Diabetic PeriosteumDOI 10.1101/2025.11.19.689158
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