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Article

KDM3B Regulates Postradiation Fibrotic Responses in Prostate Stroma via N6-methyladenosine Modification of LOX.

International journal of radiation oncology, biology, physics - 15 Nov 2025

Dong Antao, Sun Xin, Chen Lei, Tsai Ying, Kerns Sarah, Marples Brian, Xing Defu, Chen Yuhchyau, Xie Dongdong, Sun Yin

Abstract excerpt

PURPOSE: Genome-wide association studies have uncovered single-nucleotide polymorphisms (SNPs) linked to radiation therapy (RT)-induced toxicities in patients with prostate cancer. SNP rs17599026, located in intron 21 of the KDM3B gene, has been associated with late-onset urinary toxicity, with an increased frequency of urination observed 2 years post-RT compared with pretreatment conditions. This study aimed to...

Read the complete abstract on PubMed

Topics

Male
Animals
Fibrosis
Mice

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Jumonji Domain-Containing Histone Demethylases

Prostatic Neoplasms

Adenosine

Prostate

Protein-Lysine 6-Oxidase

Polymorphism, Single Nucleotide

Humans

Stromal Cells

Source

Identifiers

PMID: 40588066
DOI: 10.1016/j.ijrobp.2025.06.3851

Genes

KDM3B
LOX

Provenance

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