Article

Endothelial CLK2 as a therapeutic target for acute radiation syndrome

2025-11-07

Abstract excerpt

Damage to the vascular endothelium is a major contributor to acute radiation injury in multiple organs that underlies acute radiation syndrome (ARS), yet there are no FDA-approved radiation countermeasures targeting endothelial cells. Use of kinome-scale CRISPR screens performed in cultured human vascular endothelial cells isolated from different organs identified CLK2 as a potential radioprotective target. Pharma...

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Literature Corpus work: 0b25be42-f2da-54a2-9ac1-276d9fa70176
DOI: 10.1101/2025.11.05.686891

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