Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction

11 Feb 2020

Abstract excerpt

Abstract Purpose: Epigenetic deregulation is deeply implicated in the pathogenesis of bladder cancer. KDM6A (Lysine (K)-specific demethylase 6A) is a histone modifier frequently mutated in bladder cancer. However, the molecular mechanisms of how KDM6A deficiency contributes to bladder cancer development remains largely unknown. We hypothesized that clarification of the pathogenic mechanisms underlying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bladder and Urothelial Cancer Treatments
Share to Epigenetics and DNA Methylation
Share to Immune cells in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32047002
DOI: 10.1158/1078-0432.ccr-19-2230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 DysfunctionPMID 32047002Read ↗

Significance of KDM6A mutation in bladder cancer immune escape.Semantic proximity Read ↗

Significance of KDM6A Mutation in Bladder Cancer Immune EscapeSemantic proximity Read ↗

Significance of KDM6A Mutation in Bladder Cancer Immune EscapeSemantic proximity Read ↗

X chromosome protects against bladder cancer in females via a KDM6A-dependent epigenetic mechanism.Semantic proximity Read ↗

Loss of KDM6A-mediated genomic instability and metabolic reprogramming regulates response to therapeutic perturbations in bladder cancer.Semantic proximity Read ↗

Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.Semantic proximity Read ↗

Y-Linked Lysine(K) Demethylase 5D as a regulator of sex-specific bladder cancer metastasis and prognosisSemantic proximity Read ↗

Loss of KDM6A-mediated genomic instability and metabolic reprogramming differentially regulates responses to immune checkpoint therapy and chemotherapy in bladder cancerSemantic proximity Read ↗

A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer.Semantic proximity Read ↗

A Pan-Cancer Analysis Revealing the Dual Roles of Lysine (K)-Specific Demethylase 6B in Tumorigenesis and ImmunitySemantic proximity Read ↗

KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder CancerSemantic proximity Read ↗

Molecular pathology of urothelial carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.