Article

Loss of KDM6A-mediated genomic instability and metabolic reprogramming differentially regulates responses to immune checkpoint therapy and chemotherapy in bladder cancer

2024-11-03

Abstract excerpt

Mutations in genes encoding critical epigenetic regulators are frequently noted in bladder cancer, however, the impact of these mutations on therapeutic efficacy is unclear. One of the most common driver mutations in bladder cancer occurs in the KDM6A gene, which encodes a histone demethylase that promotes gene transcription. Retrospective analyses of patients with bladder cancer demonstrated that KDM6A mutation...

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Literature Corpus work: e94d0920-edba-5061-98c4-fafb92aa68ea
DOI: 10.1101/2024.10.31.621396

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