Article

Molecular mechanisms of dynamics-mediated effects of pathogenic missense mutations on Menin protein function

2024-12-25

Abstract excerpt

Understanding how disease-causing missense mutations (DCMMs) affect protein function is fundamental. The traditional structure-function paradigm for proteins has evolved into a structure-dynamics-function model, as dynamics is increasingly recognized as a key regulator of protein function. Consequently, it is essential to incorporate dynamics into the once heavily emphasized structure-function framework to explain...

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Literature Corpus work: 9b002c05-4f6c-5a25-9239-872ef3031db8
DOI: 10.1101/2024.12.22.630010

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