Article
Positive association of the DIO2 (deiodinase type 2) gene with mental retardation in the iodine-deficient areas of China.
Journal of medical genetics - 1 Aug 2004
Guo T-W, Zhang F-C, Yang M-S, Gao X-C, Bian L, Duan S-W, Zheng Z-J, Gao J-J, Wang H, Li R-L, Feng G-Y, St Clair D, He L
Abstract excerpt
BACKGROUND: Iodine deficiency is the commonest cause of preventable mental retardation (MR) worldwide. However, in iodine-deficient areas not everyone is affected and familial aggregation is common. This suggests that genetic factors may also contribute. Thyroid hormone (TH) plays an important role in fetal and early postnatal brain development. The pro-hormone T4 (3,3',5,5'-triiodothyronine) is converted in the...
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