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Article

Loss of integrin alpha7-mediated signaling induces a dendritic cell-like phenotype in macrophages cultured on laminin-211/221 isoforms.

The Journal of biological chemistry - 1 Aug 2025

Yoshiba Nagako, Maekawa Tomoki, Sekiguchi Kiyotoshi, Kaku Masaru, Sirisereephap Kridtapat, Surboyo Meircurius, Sato-Yamada Yurie, Rosenkranz Andrea, Hosoya Akihiro, Ohkura Naoto, Kakihara Yoshito, Maeda Takeyasu, Hajishengallis George, Izumi Kenji, Yoshiba Kunihiko

Abstract excerpt

Laminin comprises α/β/γ subunits and performs tissue-specific functions that control cellular behavior. Laminin-α2 chains are highly expressed in neural components such as glial and Schwann cells and in muscles. Macrophages play important roles in tissue homeostasis and repair, and laminins affect macrophage dynamics. Integrin α7, a transmembrane receptor crucial for regulating cell-matrix interactions, has a...

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Share to alpha7 Nicotinic Acetylcholine Receptor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40578559
DOI: 10.1016/j.jbc.2025.110419
PMCID: PMC12301786

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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