Article
Laminin and fibronectin treatment leads to generation of dendritic cells with superior endocytic capacity.
PloS one - 19 Apr 2010
García-Nieto Samuel, Johal Ramneek K, Shakesheff Kevin M, Emara Mohamed, Royer Pierre-Joseph, Chau David Y S, Shakib Farouk, Ghaemmaghami Amir M
Abstract excerpt
BACKGROUND: Sampling the microenvironment at sites of microbial exposure by dendritic cells (DC) and their subsequent interaction with T cells in the paracortical area of lymph nodes are key events for initiating immune responses. Most of our knowledge of such events in human is based on in vitro studies performed in the absence of extracellular matrix (ECM) proteins. ECM in basement membranes and interstitial...
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