Article

Human Laminin-111 and Laminin-211 protein therapy prevents muscle disease progression in an immune deficient mouse model of LAMA2-CMD

2020-05-20

Abstract excerpt

<title>Abstract</title> <p>Background Laminin-α2 related Congenital Muscular dystrophy (LAMA2-CMD) is a devastating genetic disease caused by mutations in the LAMA2 gene. These mutations result in progressive muscle wasting and inflammation leading to delayed milestones, and reduced lifespan in affected patients. There is currently no cure or treatment for LAMA2-CMD. Preclinical studies have demonstrated that mou...

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Literature Corpus work: 4bc02f26-39d9-50c9-89fa-d5e7d032c8e1
DOI: 10.21203/rs.3.rs-29430/v1

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