Woolf et al's "GWAS by subtraction" is not useful for cross-generational Mendelian randomization studies.

Abstract excerpt

Mendelian randomization (MR) is an epidemiological method that can be used to strengthen causal inference regarding the relationship between a modifiable environmental exposure and a medically relevant trait and to estimate the magnitude of this relationship [1]. Recently, there has been considerable interest in using MR to examine potential causal relationships between parental phenotypes and outcomes amongst...

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