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Spatial omics reveals molecular changes in focal cortical dysplasia type II

2 Apr 2024

Abstract excerpt

Focal cortical dysplasia (FCD) represents a group of diverse localized cortical lesions that are highly epileptogenic and occur due to abnormal brain development caused by genetic mutations, involving the mammalian target of rapamycin (mTOR). These somatic mutations lead to mosaicism in the affected brain, posing challenges to unravel the direct and indirect functional consequences of these mutations. To...

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PMID: 38575092
DOI: 10.1016/j.nbd.2024.106491

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