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Misalignment of age clocks

25 Jun 2025

Abstract excerpt

Biological aging is a complex non-linear process, with markedly distinct starting and end points, yet the biomarkers of its progression remain elusive. A key assumption of most machine learning (ML) approaches for age clocks is that predictive biomedical features can be identified via mathematical transformations of data to favor a linear transition from start to end, even if they erase any natural biological...

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PMID: 40560445
DOI: 10.1007/s11357-025-01750-2

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