Article

DNA methylation clocks struggle to distinguish inflammaging from healthy aging, but feature rectification improves coherence and enhances detection of inflammaging

2024-10-13

Abstract excerpt

Biological age estimation from DNA methylation and determination of relevant biomarkers is an active research problem which has predominantly been tackled with black-box penalized regression. Machine learning is used to select a small subset of features from hundreds of thousands CpG probes and to increase generalizability typically lacking with ordinary least-squares regression. Here, we show that such feature se...

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Literature Corpus work: 7e90638e-0ba3-5f70-8e3f-8d430cc02b36
DOI: 10.1101/2024.10.09.617512

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DNA methylation clocks struggle to distinguish inflammaging from healthy aging, but feature rectification improves coherence and enhances detection of inflammagingDOI 10.1101/2024.10.09.617512Read

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