Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma.

Scientific reports - 24 Dec 2025

Wang Hong-Gang, Lu Ming-Xia, Sheng Mei-Ling, Lou Ya-Bo, Xiao Yuan-Chao, Guo An, Yu Zheng-Hong

Abstract excerpt

Shikonin (SH) is a natural component extracted from Lithospermum erythrorhizon Siebold & Zucc, a traditional Chinese medicine, which has been shown to have anti-tumor effects in recent years. However, the specific mechanism behind these effects has not yet been reported. Thus, it is important to clarify the specific anti-tumor mechanism of SH and then develop it as a new anti-tumor drug. The objective of this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A549 Cells
Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Movement

Share to Down-Regulation

Share to Hedgehog Proteins

Share to Mice, Nude

Share to Naphthoquinones

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 41444284
DOI: 10.1038/s41598-025-28080-9
PMCID: PMC12738551

Genes

CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma.PMID 41444284Read ↗

Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis InductionSemantic proximity Read ↗

Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway.Semantic proximity Read ↗

Shikonin induces the apoptosis and pyroptosis of EGFR-T790M-mutant drug-resistant non-small cell lung cancer cells via the degradation of cyclooxygenase-2.Semantic proximity Read ↗

Corynoxine suppresses lung adenocarcinoma proliferation and metastasis via inhibiting PI3K/AKT pathway and suppressing Cyclooxygenase-2 expressionSemantic proximity Read ↗

Shikonin triggers apoptosis in lung adenocarcinoma through FHL2-FOXO1 signaling axisSemantic proximity Read ↗

Migration Suppression of Small Cell Lung Cancer by Polysaccharides from <i>Nostoc commune</i> VaucherSemantic proximity Read ↗

Radix Sophorae Flavescentis (Kushen) inhibits NSCLC by targeting miR-183-5p/EGR1 and PTEN/AKt pathwaySemantic proximity Read ↗

Shikonin sensitizes A549 cells to TRAIL-induced apoptosis through the JNK, STAT3 and AKT pathwaysSemantic proximity Read ↗

Shikonin causes apoptosis by up-regulating p73 and down-regulating ICBP90 in human cancer cellsSemantic proximity Read ↗

A Potent EGFR Inhibitor, N-Phenyl Pyrazoline Derivative Suppresses Aggressiveness and Cancer Stem Cell-Like Phenotype of Cervical Cancer Cells.Semantic proximity Read ↗

Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer CellsSemantic proximity Read ↗

Ellagic Acid and Cancer Hallmarks: Insights from Experimental EvidenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.