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Stemness and inducing differentiation of small cell lung cancer NCI-H446 cells

16 May 2013

Abstract excerpt

Small cell lung cancer (SCLC) accounts for nearly 15% of human lung cancers and is one of the most aggressive solid tumors. The SCLC cells are thought to derive from self-renewing pulmonary neuroendocrine cells by oncogenic transformation. However, whether the SCLC cells possess stemness and plasticity for differentiation as normal stem cells has not been well understood thus far. In this study, we investigated...

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PMID: 23681228
DOI: 10.1038/cddis.2013.152

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