A genome-wide association study identifies three loci associated with mean platelet volume.

doi:10.1016/j.ajhg.2008.11.015

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Article

A genome-wide association study identifies three loci associated with mean platelet volume.

American journal of human genetics - 1 Jan 2009

Meisinger Christa, Prokisch Holger, Gieger Christian, Soranzo Nicole, Mehta Divya, Rosskopf Dieter, Lichtner Peter, Klopp Norman, Stephens Jonathan, Watkins Nicholas A, Deloukas Panos, Greinacher Andreas, Koenig Wolfgang, Nauck Matthias, Rimmbach Christian, Völzke Henry, Peters Annette, Illig Thomas, Ouwehand Willem H, Meitinger Thomas, Wichmann H-Erich, Döring Angela

Abstract excerpt

Mean platelet volume (MPV) is increased in myocardial and cerebral infarction and is an independent and strong predictor for postevent morbidity and mortality. We conducted a genome-wide association study (GWAS), the KORA (Kooperative Gesundheitsforschung in der Region Augsburg) F3 500K study, and found MPV to be strongly associated with three common single-nucleotide polymorphisms (SNPs): rs7961894 located...

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Identifiers

PMID: 19110211
DOI: 10.1016/j.ajhg.2008.11.015
PMCID: PMC2668036

Genes

ARHGEF3
TAOK1

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