Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A pathologically expanded, clonal lineage of IL-21–producing CD4+ T cells drives inflammatory neuropathy

11 Jun 2024

Abstract excerpt

Inflammatory neuropathies, which include chronic inflammatory demyelinating polyneuropathy (CIDP) and Guillain Barré syndrome (GBS), result from autoimmune destruction of the PNS and are characterized by progressive weakness and sensory loss. CD4+ T cells play a key role in the autoimmune destruction of the PNS. Yet, key properties of pathogenic CD4+ T cells remain incompletely understood. Here, we used paired...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermatology and Skin Diseases
Share to Peripheral Neuropathies and Disorders
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39087473
DOI: 10.1172/jci178602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A pathologically expanded, clonal lineage of IL-21–producing CD4+ T cells drives inflammatory neuropathyPMID 39087473Read ↗

A pathologically expanded, clonal lineage of IL-21 producing CD4+ T cells drives Inflammatory neuropathySemantic proximity Read ↗

Single-cell analysis reveals novel clonally expanded monocytes associated with IL1β-IL1R2 pair in acute inflammatory demyelinating polyneuropathySemantic proximity Read ↗

Nerve-targeting and pain-promoting transcriptomic signatures in early Guillain-Barré syndromeSemantic proximity Read ↗

Bystander memory-phenotype conventional CD4 <sup>+</sup> T cells exacerbating autoimmune neuroinflammationSemantic proximity Read ↗

Single-cell analysis reveals novel clonally expanded monocytes associated with IL1β–IL1R2 pair in acute inflammatory demyelinating polyneuropathySemantic proximity Read ↗

A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasiaSemantic proximity Read ↗

Identification of disease-specific TCRs maintaining pathogenic T helper cell responses in postinfectious Lyme ArthritisSemantic proximity Read ↗

A transcriptional toolbox for exploring peripheral neuroimmune interactionsSemantic proximity Read ↗

Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitisSemantic proximity Read ↗

Autoreactive T cells target peripheral nerves in Guillain–Barré syndromeSemantic proximity Read ↗

Genetic analyses of inflammatory polyneuropathy and chronic inflammatory demyelinating polyradiculoneuropathy identified candidate genes.Semantic proximity Read ↗

Steady-state memory-phenotype conventional CD4+ T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40/GM-CSF axis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.