Insights from human NF-κB knockouts.

Abstract excerpt

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in humans now allow initial insights into non-essential human genes in which both alleles carry mutations that prevent protein expression or function. Here, we compiled the non-essential genes identified in various sequencing studies and analyzed the occurrence of knockouts in the human NF-κB...

Topics

• Humans
• NF-kappa B
• Signal Transduction
• Protein Processing, Post-Translational
• Gene Knockout Techniques
• Mutation
• Genome, Human